Neuroinflammation in the Central Nervous System: Exploring the Evolving Influence of Endocannabinoid System

Neuroinflammation is a complex biological process that typically originates as protective response in the brain. This inflammatory triggered by release of pro-inflammatory substances like cytokines, prostaglandins, and reactive oxygen nitrogen species from stimulated endothelial glial cells, including those with functions, outer regions. While neuronal inflammation common various central nervous system disorders, specific pathways linked different immune-mediated cell types factors influencing blood-brain barrier significantly contribute to disease-specific characteristics. The endocannabinoid consists cannabinoid receptors, endogenous cannabinoids, enzymes responsible for synthesizing metabolizing endocannabinoids. primary receptor CB1, predominantly found brain regions such brainstem, cerebellum, hippocampus, cortex. presence CB2 receptors certain components, cultured cerebellar granular Purkinje fibers, microglia, well areas cerebral cortex, cerebellum also evidenced immunoblotting assays, radioligand binding, autoradiography studies. Both CB1 exhibit noteworthy physiological responses possess diverse neuromodulatory capabilities. review primarily aims outline distribution across explore their potential roles regulating neuroinflammatory processes.